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Cassie attempts to hide her own struggles with mental health while her flamboyant parents ignore her in favour of their new baby.
Chris Miles (Joe Dempsie) is the party animal of the group.
"Posh" Kenneth (Daniel Kaluuya) goes to the same college as the main cast and often spends time with the boys.
Madison "Mad" Twatter (Stephen Walters) features as Sid's emergency drug dealer, Doug (Giles Thomas) is a senior teacher at Roundview College, and British comedian and co-writer Josie Long appears as the college's careers counsellor.
While he takes a pick-and-choose approach to Islam, and has no qualms about indulging in premarital sex and usage of alcohol and drugs in spite of his religion's policies against them, he has some difficulty fully accepting Maxxie's sexuality.
Appearing only in the second series, Lucy, better known as "Sketch" (Aimee-Ffion Edwards), is a quiet and scheming Welsh girl who is polite yet unnerving.
He is portrayed as attractive, seductive and talented, and is well accepted by most of his friends and family.
Tony's girlfriend is Michelle Richardson (April Pearson), a girl who can never stay angry at his mischievous behaviour for long.
Living two buildings over and having a clear view of his room, she develops an obsession for Maxxie and becomes his stalker.
Without her father, she is a young carer for her mother Sheila, who suffers from multiple sclerosis.
The central cast's parents are often played by well-known British actors credited in a guest starring role.
Harry Enfield and Morwenna Banks act as Tony and Effy's parents, Jim and Anthea Stonem.